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Lai Y-T, Hsieh C-W, Lo Y-C, Liou B-K, Lin H-W, Hou C-Y, et al

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14.2 Weight Management Trial in Pediatric Patients Ages 12 and Older with Obesity SAXENDA was evaluated in a 56-week, double-blind, randomized, parallel group, placebo controlled multi-center trial in 251 pubertal pediatric patients aged 12 to 17 years, with BMI corresponding to 30 kg/m2 or greater for adults by international cut-off points1 and BMI of 95th percentile or greater for age and sex (NCT02918279)

Goldman DP, Zheng Y, Girosi F, et al

These proteolytic fragments, particularly of IGFBP-5 and -3, may also have ligand-independent biological activity [66, 67]